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Applied Clinical Pharmacokinetics, 2e
| Part III. Cardiovascular Agents > |
Chapter 8. Procainamide/N-Acetyl Procainamide
Sections: Procainamide/N-Acetyl Procainamide: Introduction, Therapeutic and Toxic Concentrations, Clinical Monitoring Parameters, Basic Clinical Pharmacokinetic Parameters, Effects of Disease States and Conditions on Procainamide Pharmacokinetics and Dosing, Drug Interactions, Initial Dosage Determination Methods, Use of Procainamide and N-Acetylprocainamide Serum Concentrations to Alter Doses, Chiou Method, Bayesian Pharmacokinetic Computer Programs, Use of Procainamide Booster Doses to Immediately Increase Serum Concentrations, Dosing Strategies, Conversion of Procainamide Doses from Intravenous to Oral Route of Administration, Problems, Answers to Problems, References.
Topics Discussed: acecainide; arrhythmias; drugs affecting cardiovascular function; procainamide.
Excerpt:"Procainamide is an antiarrhythmic agent that is used intravenously
and orally. It is classified as a type IA antiarrhythmic agent and
can be used for the treatment of supraventricular or ventricular
arrhythmias.1,2 It is a drug of choice for the treatment
of stable sustained monomorphic ventricular tachycardia.3 Procainamide
is a useful agent in the treatment of idiopathic repetitive polymorphic
ventricular tachycardia in patients with coronary heart disease.
It can also be used to treat incessant or recurrent polymorphic
ventricular tachycardia secondary to acute myocardial ischemia after
revasculariztion has been performed and  -blockers
have been administered.3..."
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