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Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e
| Section III. Modulation of Cardiovascular Function > |
Antiplatelet Drugs
Sections: Aspirin, Dipyridamole, Ticlopidine (Ticlid, Others), Adverse Effects, Therapeutic Uses, Clopidogrel (Plavix), Prasugrel (Effient or Efient), Glycoprotein IIb/IIIa Inhibitors, Abciximab, Adverse Effects, Eptifibatide, Adverse Effects, Tirofiban, Newer Antiplatelet Agents, Cangrelor, Ticagrelor, Sch530348.
Topics Discussed: abciximab; antiplatelet agents; aspirin; blood coagulation; cangrelor; chemistry of anticoagulants; clopidogrel; coagulation disorders; dipyridamole; eptifibatide; hemostatic function; pharmacotherapy of hematologic disorders; platelet glycoprotein iib/iiia inhibitors; prasugrel; thromboembolism; ticagrelor; ticlopidine; tirofiban; venous thromboembolism; vorapaxar.
Excerpt:"Platelets provide the initial hemostatic plug at sites of vascular injury. They also participate in pathological thromboses that lead to myocardial infarction, stroke, and peripheral vascular thromboses. Potent inhibitors of platelet function have been developed in recent years. These drugs act by discrete mechanisms; thus, in combination, their effects are additive or even synergistic. Their availability has led to a revolution in cardiovascular medicine, whereby angioplasty and vascular stenting of lesions now are feasible with low rates of restenosis and thrombosis when effective platelet inhibition is employed. The sites of pharmacological intervention by the various antiplatelet drugs are highlighted in Figure 30–8.Processes including thrombosis, inflammation, wound healing, and allergy are modulated by oxygenated metabolites of arachidonate and related polyunsaturated fatty acids that are collectively termed eicosanoids. Interference with the synthesis of eicosanoids is the basis for the effects of many therapeutic agents, including analgesics, anti-inflammatory drugs, and anti-thrombotic agents (see Chapters 33 and 34).The most common side effects are nausea, vomiting, and diarrhea. The most serious..."
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